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1959) created a new field of medicine-medical cytogenetics. Speculations that some congenital anomalies in man such as mongolism might be caused by chromosomal abnormalities were made as early as the 1930s. Said Waardenburg (1932): "I would like to urge cytologists to consider the possibility that in mongolism lies an example of specific chromosome aberration in man. . " Bleyer (1934) also 39 Funny Looking Kids suggested trisomy as the possible cause of this common developmental defect. Ursula Mittwoch (1952) actually examined spermatocytes of a mongol patient but failed to find aneuploidy .

Being so polite, he usually answered "yes" to whatever question he was asked, without understanding the question. " One evening, I took Makino to my apartment with a friend of mine to have dinner, and I did the cooking. As we finished the dinner, Makino stood up, bowed, and thanked me. My friend then asked, "Well, Dr. Makino, are you now convinced that Dr. " "No," he replied and solemnly sat down. I am sure he was telling the truth, but that is not the usual habit of the polite Japanese people.

Court Brown, for his contribution to human genetics. Court Brown was probably the least known among human cytogeneticists ofthat period. In technical papers, his name seldom appeared as senior author; he let his associates receive the glamour and placed himself in the background. It was Court Brown who created the Medical Research Council Unit in the Western General Hospi- 42 6. Funny Looking Kids tal of Edinburgh, Scotland, where many important advances have been made. Investigations by Baikie, Bucton, Harden, Jacobs, McLean, Tough, and others were all, in large measure, made possible by the background and atmosphere created by Court Brown.

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