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Martino, E. (2003). Effects of a mixture of polychlorinated biphenyls (Aroclor 1254) on the transcriptional activity of thyroid hormone receptor. Journal of Endocrinological Investigation, 26, 10, (October 2003), pp. 972-8. M. C. (2002). Towards a global historical emission inventory for selected PCB congeners--a mass balance approach. 1. Global production and consumption. The Science of the Total Environment, 290, 1-3, (May 2002), pp. 181-98. ; Bergman, A. J. (1998). Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health.

A) (b) Fig. 1. Chemical structure of triiodothyronine (a) and thyroxine (b). , 2006b). , 1998; Brucker-Davis, 1998). Chemical interference with uptake of iodide by the thyroid gland and, more specifically with the sodium/iodide symporter (which facilitates the iodide uptake), can result as decrease in the circulating levels of T4/T3 (Wolff, 1998). , 1997). g. , 1991). Environmental Thyroid Disruptors and Human Endocrine Health 23 Fig. 2. Feedback mechanisms of thyroid system homeostasis (modified from Boas M et al.

115-141. ; Kondo, F. & Katayama, Y. (2006). Human exposure to bisphenol A. Toxicology 226, 2-3, (September 2006), pp. 79-89. H. M. (2004). Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. Environmental Science & Technology, 38, 17, (September 2004), pp. 4489– 4495. ; Inoue, T. & Degawa, M. (2004). A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Toxicological Sciences, 81, 2, (October 2004), pp.

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